Radical Curative Activity of a New 8-Aminoquinoline Derivative (CDRI 80/53) against Plasmodium cynomolgi B in Monkeys
- 1 December 1989
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 41 (6), 635-637
- https://doi.org/10.4269/ajtmh.1989.41.635
Abstract
An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg × 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.This publication has 2 references indexed in Scilit:
- Methemoglobin Toxicity and Hematological Studies on Malaria Anti-Relapse Compound CDRI 80/53 in DogsThe American Journal of Tropical Medicine and Hygiene, 1989
- Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeysAntimicrobial Agents and Chemotherapy, 1983