Cdk5 phosphorylates p53 and regulates its activity
Open Access
- 20 April 2002
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 81 (2), 307-313
- https://doi.org/10.1046/j.1471-4159.2002.00824.x
Abstract
Cyclin dependent kinase 5 (Cdk5) is a proline‐direct protein kinase that is most active in the CNS, and has been implicated as a contributing factor in certain neurodegenerative diseases. Further, th...Keywords
This publication has 43 references indexed in Scilit:
- A decade of CDK5Nature Reviews Molecular Cell Biology, 2001
- Neurons Are Protected from Excitotoxic Death by p53 Antisense Oligonucleotides Delivered in Anionic LiposomesPublished by Elsevier ,2001
- Stoichiometric Phosphorylation of Human p53 at Ser315Stimulates p53-dependent TranscriptionJournal of Biological Chemistry, 2001
- Neuronal life and death: an essential role for the p53 familyCell Death & Differentiation, 2000
- The role of p53 in neuronal cell deathCell Death & Differentiation, 2000
- DNA damage activates p53 through a phosphorylation–acetylation cascadeGenes & Development, 1998
- Apoptosis and the cell cycle: the p53 connectionCell Death & Differentiation, 1998
- Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma ProteinPublished by Elsevier ,1997
- Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinasesNature, 1995
- Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.The Journal of cell biology, 1991