Results of a program designed to control neonatal porcine coccidiosis on a total confinement, farrow-to-finish swine farm are reported. The control program consisted of washing, phenol disinfection, and steam cleaning of farrowing houses and treatment of sows with amprolium HCl before and after farrowing. Before initiation of the control program, 88.9% of the sows examined in the farrowing house were negative for coccidian oocysts, 9.9% were positive for Eimeria spp, and 1.2% were positive for I. suis. Most pigs nursing on sows before initiation of the control program had diarrhea at 5-10 days of age, which led to dehydration and weight loss. Morbidity was high and mortality was moderate. Composite fecal samples from these litters were all positive (100%) for I suis. After initiation of the control program, 99.6% of the sows examined in the farrowing house were negative for coccidian oocysts and 0.4% were positive for Eimeria spp. Clinical signs of coccidiosis were rarely present in nursing pigs examined after the control program was initiated; I. suis was still present in 19.8% of the composite fecal samples from pigs examined. As association between oocyst production in sows and I. suis infections in pigs was not found in the present study. Oocysts of Eimeria spp were not found in the feces from the pigs.