Studies on Unusual Amino Acids and Their Peptides. X. The Convenient Synthesis of t-Leucine and the Optical Resolution of the N-Benzyloxycarbonyl Derivative
- 1 May 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 52 (5), 1539-1540
- https://doi.org/10.1246/bcsj.52.1539
Abstract
t-Leucine has been conveniently prepared on a large scale from the phenylhydrazone of trimethylpyruvic acid, which was readily obtained as a precipitate from the oxidation of pinacolone. The N-benzyloxycarbonyl derivative of DL-t-leucine has been resolved with quinine and quinidine in ethanol.Keywords
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