Human Immunodeficiency Virus: The Eighth Gene
- 1 January 1987
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 3 (1), 33-39
- https://doi.org/10.1089/aid.1987.3.33
Abstract
Human T-lymphotropic virus type III (HTLV-III/LAV) has been shown to contain at least four extra genes in addition to the three essential genes (gag, pol, env) for replication of most retroviruses. These genes are expressed by complex splicing mechanisms and utilization of overlapping reading frames. We now demonstrate that there is an eighth gene which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. The gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3′ end which distinguishes several molecular clones of the HTLV-IIIB cell line from those of other HTLV-III/LAV isolates. The function of this gene is unknown.This publication has 23 references indexed in Scilit:
- Infectious Mutants of HTLV-III with Changes in the 3′ Region and Markedly Reduced Cytopathic EffectsScience, 1986
- Human T-Cell Lymphotropic Virus Type III (HTLV-III) Core Antigens: Synthesis inEscherichia coliand Immunoreactivity with Human SeraDNA, 1986
- The trans-activator gene of the human T cell lymphotropic virus type III is required for replicationCell, 1986
- Identification of HTLV-III/LAV sor Gene Product and Detection of Antibodies in Human SeraScience, 1986
- The Walter Reed Staging Classification for HTLV-III/LAV InfectionNew England Journal of Medicine, 1986
- Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type IIIScience, 1985
- Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)Science, 1985
- A molecular clone of HTLV-III with biological activityNature, 1985
- Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)Science, 1985
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985