Liposyn infusion increases plasma prostaglandin concentrations

Abstract

To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE₂ and PGI₂ (as measured by its metabolite 6‐keto‐PGF_1α), and two vasoconstrictors, thromboxane (TX) A₂, and PGF_2α, as measured by their metabolites TXB₂ and PGF_2α‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE₂ and 6‐keto‐PGF_1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF_2α‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao₂ of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE₂, 6‐keto‐PGF_1α, and TXB₂.