Treatment of Unresectable Pancreatic Carcinoma with 5-Fluorouracil, Vincristine, and CCNU

Abstract

Forty-seven patients with unoperable pancreatic cancer were included in a controlled, prospective study of combination chemotherapy. Twenty-five of the patients were allocated to cyclic treatment with 5-fluorouracil, CCNU [lomustinum], and vincristine in accordance with a special schedule. The other 22 patients served as untreated controls. There were no differences between the 2 groups with regard to survival time or quality of life. Side effects of the drugs given were common in the treatment group.