THE EFFECT OF LIDOCAINE ON THE PROCESSING OF SOLUBLE IMMUNE AGGREGATES AND IMMUNE-COMPLEXES BY PERITONEAL-MACROPHAGES
- 1 January 1980
- journal article
- research article
- Vol. 41 (1), 237-244
Abstract
In a search for new techniques which could specifically identify the various steps of the handling of immune complexes by guinea pig macrophages the local anesthetic, lidocaine, was investigated. Lidocaine inhibited selectively the digestion of immune complexes and immunoglobulin aggregates by macrophages but it had little effect on the binding or ingestion steps. Due to the reversible inhibitory effect of lidocaine, this drug may be used in future studies to assess the role of extracellular stimuli on the fate of intracellular immune complexes.This publication has 12 references indexed in Scilit:
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