Evidence for a Direct Effect of Angiotensin-II on Adrenal Cortex of the Dog.

Abstract

In 6 nephrectomized hypophy-sectomized dogs, the increase in aldosterone and 17-hydroxycorticoid secretion produced by infusion of angiotensin-n into the arterial blood supplying the adrenal gland was greater than the increase produced by infusion of the same dose into the jugular vein. It is concluded that angiotensin-n can stimulate adrenocortical secretion by a direct action on the adrenal gland.