INTERACTIONS OF SYMPATHOMIMETIC DRUGS AND THEIR ANTAGONISTS ON THE ISOLATED ATRIUM
Open Access
- 1 October 1961
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 17 (2), 232-235
- https://doi.org/10.1111/j.1476-5381.1961.tb01283.x
Abstract
In the isolated guinea-pig atrium, phenoxybenzamine and other antagonists of sympathomimetic drugs and the adrenergic nerve blocking agent guanethidine inhibited the action of butyrylcholine and tyramine and potentiated the action of noradrenaline. Also in the isolated guinea-pig atrium, phenoxybenzamine and cocaine abolished the parasympathetic, and potentiated the sympathetic, effects of vagus stimulation.Keywords
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