p53 and Brain Tumors: From Gene Mutations to Gene Therapy
- 1 October 1998
- journal article
- review article
- Published by Wiley in Brain Pathology
- Vol. 8 (4), 599-613
- https://doi.org/10.1111/j.1750-3639.1998.tb00187.x
Abstract
The p53 tumor suppressor gene (TP53) is the most frequently altered gene in human cancer and is also found mutated in several types of brain tumors. Loss of p53 function plays a central role in the development of cancer. The characterization of the biochemical pathways by which p53 alteration triggers tumorigenesis is the foundation for the design of novel therapeutic approaches.Keywords
This publication has 97 references indexed in Scilit:
- Tumor Eradication by Wild-type p53-specific Cytotoxic T LymphocytesThe Journal of Experimental Medicine, 1997
- Intracavitary Liposome-Mediated p53 Gene Transfer into Glioblastoma with Endogenous Wild-Type p53in VivoResults in Tumor Suppression and Long-Term SurvivalBiochemical and Biophysical Research Communications, 1997
- Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 proteinOncogene, 1997
- Association ofp53 gene mutation with decreased chemosensitivity in human malignant gliomasInternational Journal of Cancer, 1996
- Inhibition of Angiogenesis by Thrombospondin-2Biochemical and Biophysical Research Communications, 1995
- A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient miceNature Genetics, 1995
- Growth inhibition of rat glioma cellsin vitro andin vivo by aspirinJournal of Neuro-Oncology, 1995
- p53 Status and the Efficacy of Cancer Therapy in VivoScience, 1994
- Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic MutationsScience, 1994
- Timing and role of p53 gene mutation in the recurrence of gliomaBiochemical and Biophysical Research Communications, 1991