Species Reactivity to Staphylokinase.

Abstract

In fibrinolytic tests involving addition of bacterial culture product to thrombin-clotted plasmas, with and without an enzyme-inhibitor (soybean antiprotease), definite species differences in reactivity of plasmas are demonstrated to staphylokinase and streptokinase activation of the plasma protease system. Whereas streptokinase acts only on human materials, staphylokinase works on plasma (or serum) of dog, guinea pig, and rabbit also, but gives negative results with bovines and some other species tested. Staphylokinase also differs from streptokinase in requiring an incubation period of 30-60 min. before reaching optimal activation of the serum proenzyme.