Striatal Efferent Fibers Play a Role in Maintaining Rotational Behavior in the Rat
- 7 October 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4312), 62-64
- https://doi.org/10.1126/science.897683
Abstract
Rats in which ascending dopamine-containing neurons have been unilaterally destroyed by injections of 6-hydroxydopamine are known to rotate after being injected with apomorphine or L-dopa. The rotation is markedly reduced by either (i) ipsilateral electrocoagulations of the caudate-putamen or internal capsule or (ii) ipsilateral coronal knife cuts immediately rostral to the substantia nigra. Neostriatal efferent fibers, in particular the strionigral projection, appear to be required for the expression of this dopamine-dependent behavior.This publication has 13 references indexed in Scilit:
- Apomorphine-induced restoration of drinking to thirst challenges in 6-hydroxydopamine-treated ratsPhysiology & Behavior, 1976
- Reinstatement of eating by dopamine agonists in aphagic dopamine denervated ratsPhysiology & Behavior, 1976
- Alterations in consummatory behavior following intracisternal injection of 6-hydroxydopaminePharmacology Biochemistry and Behavior, 1973
- A retracting wire knife for stereotaxic brain surgery made from a microliter syringePhysiology & Behavior, 1973
- Some evidence for the existence of dopaminergic neurons in the rat cortexBrain Research, 1973
- Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in RatsScience, 1972
- Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine systemBrain Research, 1970
- Projections of the lentiform nucleus in the monkeyBrain Research, 1966
- Topical distribution of the striatal efferents in the monkeyExperimental Neurology, 1962
- An experimental study of the course and destination of fibers arising in the head of the caudate nucleus in the cat and monkeyJournal of Comparative Neurology, 1960