Design and Evolution of a Miniature Bcl-2 Binding Protein
- 15 October 2001
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 40 (20), 3806-3809
- https://doi.org/10.1002/1521-3773(20011015)40:20<3806::aid-anie3806>3.0.co;2-b
Abstract
A major challenge for chemical biologists lies in the design of potent and selective ligands for protein surfaces. Here a protein grafting and evolution strategy is used to discover highly potent and specific miniature protein ligands (see picture) for human Bcl-2 and Bcl-XL. Miniature proteins could be used to dissect, modulate, or analyze a single protein function, irrespective of the other functions the protein may regulate within the proteome.Keywords
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