THE REACTION OF PERIPHERAL BLOOD VESSELS TO ANGIOTONIN, RENIN, AND OTHER PRESSOR AGENTS
Open Access
- 1 March 1942
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 75 (3), 305-314
- https://doi.org/10.1084/jem.75.3.305
Abstract
1. Both renin and angiotonin in small doses cause constriction of the arterioles in the ears of normal rabbits, as seen directly with the microscope. Capillaries appear unaffected while venules exhibit slight or no constriction with small doses and moderate constriction with large doses. The flow of blood through the tissues is not reduced except when very large doses are administered. Tyramine and methylguanidine sulfate in isopressor amounts act somewhat similarly. 2. Isopressor amounts of epinephrine and pitressin, by contrast, elicit severe vasoconstriction of arterioles lasting longer than that due to angiotonin, and flow of blood is sharply reduced or abolished altogether. The degree of venular constriction was also greater, while the capillaries remained unaffected. 3. The vasoconstrictor action of angiotonin on peripheral vessels in moat chambers in normal rabbit's ears is indistinguishable from that of renin, except that it is more rapid.This publication has 6 references indexed in Scilit:
- THE EFFECTS OF ANGIOTONIN ON RENAL BLOOD FLOW AND GLOMERULAR FILTRATIONAmerican Journal of Physiology-Legacy Content, 1940
- A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATORThe Journal of Experimental Medicine, 1940
- THE EFFECTS OF PRESSOR DRUGS AND OF SALINE KIDNEY EXTRACTS ON BLOOD PRESSURE AND SKIN TEMPERATURE 1JCI Insight, 1938
- Observations on polymorphonuclear leukocytes in the living animalJournal of Anatomy, 1936
- Observations on changes in blood vascular endothelium in the living animalJournal of Anatomy, 1935
- A method of studying the effects of chemicals upon living cells and tissues in the moat chamber, a transparent chamber inserted in the rabbit's earThe Anatomical Record, 1932