Influenza Virus Proliferation in Hypoxic Mice

Abstract

Expts. on the rate of growth of influenza virus in mice rendered hypoxic in a decompression chamber revealed that the rate of proliferation of influenza virus is low in the intact hypoxic animal as compared with the normally oxygenated one. These findings tend to support the hypothesis that the intricate syntheses involved in virus reproduction require coupled host cell oxidative mechanisms as a source of energy.