Towards the Total Synthesis of Ambruticin: Preparation of the Fully Functionalised Right-Hand Portion Using the Intramolecular Silyl-Modified Sakurai (ISMS) Annulation

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Abstract
The concise synthesis of the fully functionalised right-hand dihydropyran subunit of the antifungal antibiotic ambruticin (1), using the ISMS annulation as the key-step, is described.