Immunologic Studies on a Protein Extracted from Human Secondary Amyloid

Abstract

LITTLE is known about the specific nature of amyloid except that it takes certain stains, contains protein and carbohydrate and is laid down in the tissues as discrete fibrils. More accurate determination of its physical and chemical properties has been lacking mainly because of the difficulties encountered in attempts to separate amyloid deposits from surrounding parenchymal and connective tissues.As it became clear from work proceeding in this laboratory that amyloid fibrils could, in fact, be isolated in relatively pure form by means of differential centrifugation of tissue homogenates¹ and, of even greater import, that these fibrils could then be . . .