INVITRO EFFECTS OF PROPRANOLOL AND ATENOLOL ON NEUTROPHIL MOTILITY AND POST-PHAGOCYTIC METABOLIC-ACTIVITY

Abstract

Propranolol at concentrations of 1 .times. 10-6 to 1 .times. 10-4 M consistently increased neutrophil motility as measured in Boyden chambers. The effects were not due solely to stimulation of random migration and chemokinesis but also of directional motility. Propranolol, over a similar concentration range, caused inhibition of post-phagocytic cell metabolic activity (hexose monophosphate shunt, nitro-blue tetrazolium reduction and protein iodination) without any detectable effect on the ingestion rate of Candida albicans. Atenolol had no effect on any of these neutrophil functions. Both drugs were without effect on glycolysis and intracellular cyclic[c]AMP levels. Propranolol at concentrations which stimulated cell motility, caused increased intracellular cGMP levels. Propranolol may stimulate neutrophil motility by promoting increased intracellular cGMP levels or by decreasing neutrophil superoxide production.