Primary Tuberculosis in Children

Abstract

SINCE the introduction of effective chemotherapeutic agents for the treatment of tuberculosis, concern has been felt about the emergence of strains of Mycobacterium tuberculosis resistant to the three major antituberculosis drugs: streptomycin, isoniazid and para-amino-salicylic acid (PAS).Many studies have now appeared concerning the incidence of drug-resistant strains after treatment with antituberculosis drugs. In New York City Chaves and his associates¹ have reported that 38.9 per cent of strains of M. tuberculosis isolated from ambulatory patients previously treated and hospitalized were resistant to all three major drugs tested. The significance of the transmission of such drug-resistant organisms to others in . . .