Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs
- 1 March 1983
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 67 (3), 143-150
- https://doi.org/10.1111/j.1600-0404.1983.tb04557.x
Abstract
- The effect of 2 central nervous system glycolipids (cere-broside and ganglioside) on the encephalitogenic activity of bovine myelin basic protein (MBP) was studied in guinea pigs. Mixing each of these glycolipids with MBP and injection of these mixtures in Freund's incomplete adjuvent (FIA) abrogated the resistance to encephalomyelitis upon challenge with MBP in Freund's complete adjuvant (FCA). Primary injection of these glycolipid-MBP mixtures in FCA diminished the clinical signs of experimental allergic encephalomyelitis (EAE) as compared to primary injection of MBP in FCA. Considering the amount of ganglioside needed to optimally induce these effects, this phenomenon seemed to be aspecific. However, with cerebroside, only minor quantities were sufficient, suggesting specific interaction with the basic protein. In several aspects, close correlation was found between cellular immune activity to MBP as measured by skin reactivity and the development of EAE.Keywords
This publication has 24 references indexed in Scilit:
- Studies on the inactivation of encephalitogenic myelin basic protein by serumActa Neurologica Scandinavica, 2009
- Serum degradation of myelin basic protein with loss of encephalitogenic activity: Evidence for an enzymatic processCellular Immunology, 1978
- Inhibition by serum of encephalitogenic activity of myelin basic protein: Nature of the serum factor responsibleCellular Immunology, 1975
- Immune responses to myelin basic protein in mycobacterial-induced suppression of experimental allergic encephalomyelitisCellular Immunology, 1974
- In vitro and in vivo immune responses to homologous myelin basic protein in experimental allergic encephalomyelitisCellular Immunology, 1974
- Specific interaction of central nervous system myelin basic protein with lipids. Specific regions of the protein sequence protected from the proteolytic action of trypsinBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973
- Comparison of experimental allergic encephalomyelitis induced with spinal cord, basic protein, and synthetic encephalitogenic peptideClinical Immunology and Immunopathology, 1973
- The forebrain of the guinea pig in stereotaxic coordinatesJournal of Comparative Neurology, 1965
- EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PROTECTION EXPERIMENTS WITH ENCEPHALITOGENIC FACTOR AND TUBERCLE FRACTIONS*Annals of the New York Academy of Sciences, 1965
- Prevention of Allergic Encephalomyelitis by Prior Injection of AdjuvantsNature, 1958