Fatty acids potentiate interleukin-1β toxicity in the β-cell line INS-1E
- 9 August 2002
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 296 (1), 189-193
- https://doi.org/10.1016/s0006-291x(02)00819-7
Abstract
No abstract availableKeywords
Funding Information
- Diabetesforbundet
- Novo Nordisk Fonden
- Norges Forskningsråd (136139/310)
This publication has 20 references indexed in Scilit:
- Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell FunctionDiabetes, 2002
- Inhibition of insulin gene expression by long-term exposure of pancreatic β cells to palmitate is dependent on the presence of a stimulatory glucose concentrationMetabolism, 2000
- Fatty acid-induced β cell apoptosis: A link between obesity and diabetesProceedings of the National Academy of Sciences, 1998
- Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.Journal of Clinical Investigation, 1998
- The role of interleukin-1 in the pathogenesis of IDDMDiabetologia, 1996
- Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.Proceedings of the National Academy of Sciences, 1994
- Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.Journal of Clinical Investigation, 1994
- A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*Endocrinology, 1990
- The stimulus-secretion coupling of glucose-induced insulin release: Fuel metabolism in islets deprived of exogenous nutrientArchives of Biochemistry and Biophysics, 1983
- Stimulation of insulin secretion by infusion of free fatty acidsJournal of Clinical Investigation, 1969