Effect of renal denervation on arterial pressure in rats with aortic nerve transection.
- 1 July 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 5 (4), 468-475
- https://doi.org/10.1161/01.hyp.5.4.468
Abstract
The role of renal nerves in influencing the control of arterial pressure was studied in Wistar rats with aortic depressor nerve (ADN) transection. Renal denervation prevented or reversed the normal increase in arterial pressure seen after ADN transection. This effect was not due to an effect on the renin-angiotensin system, as the elevated arterial pressure after ADN section in rats with renal nerves intact was shown to be due to increased alpha-adrenergic activity. Food and water intake and urine output decreased significantly in both renal-denervated and sham-denervated rats after ADN section, suggesting that a pressure diuresis mechanism was not responsible for preventing the rise in pressure in renal-denervated rats. In another study, the concentration of norepinephrine in skeletal muscle and hypothalamus at 0 and 8 hours after inhibition of tyrosine hydroxylase with alpha-methyltyrosine was used as an index of norepinephrine turnover. Norepinephrine turnover in skeletal muscle was increased significantly over control values by ADN transection in sham renal-denervated rats, but was not significantly different from controls in renal-denervated rats with ADN section. In the hypothalamus, there was a significant difference between the turnover of norepinephrine in the two groups of ADN-sectioned rats. The results taken together suggest that renal denervation prevents the arterial pressure response to ADN transection by altering the central mechanisms governing sympathetic outflow. It is suggested that this effect may be due to elimination of information carried by afferent renal fibers.This publication has 24 references indexed in Scilit:
- Decrease in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat.Hypertension, 1982
- Renal denervation at weaning retards development of hypertension in New Zealand genetically hypertensive rats.Hypertension, 1982
- Changes in drinking behavior caused by superior cervical ganglionectomy and pinealectomy in ratsJournal of the Autonomic Nervous System, 1981
- Renal afferent nerves affect discharge rate of medullary and hypothalamic single units in the catJournal of the Autonomic Nervous System, 1981
- Pathogenesis of hypertension in rats with chronic aortic baroreceptor deafferentation.Hypertension, 1980
- Importance of renal sympathetic tone in the development of DOCA-salt hypertension in the rat.Hypertension, 1980
- Hypothalamic projections of renal afferent nerves in the catCanadian Journal of Physiology and Pharmacology, 1980
- Changes in renal vascular sensitivity and arterial pressure associated with sodium intake during long-term intrarenal norepinephrine infusion in dogs.Hypertension, 1979
- Renal denervation delays blood pressure increase in the spontaneously hypertensive ratCellular and Molecular Life Sciences, 1977
- Multiple Range and Multiple F TestsBiometrics, 1955