The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-β-ol into cholesterol
- 1 February 1967
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 102 (2), 462-467
- https://doi.org/10.1042/bj1020462
Abstract
The syntheses of 7-[4-C14] cholestenol and [DELTA]7-[6[alpha]-H3]-cholestenol are described. The metabolism of doubly labelled [DELTA]7-cholestenol by rat-liver homogenates was studied. During the enzymic conversion of [DELTA]7-cholestenol into cholesterol the 6[alpha] -hydrogen atom of the former is lost and the overall reaction corresponds to a cis-eliminatlon. In the light of these results various mechanisms for the conversion of [alpha]7-cholestenol into cholesterol are discussed.This publication has 5 references indexed in Scilit:
- Agents Affecting Lipid Metabolism. XVIII. A 7-Dehydrocholesterol Δ7-Reductase Inhibitor (AY-9944) as Tool in Studies of Δ7-Sterol Metabolism*Biochemistry, 1966
- Metabolic Transformations of CholestenediolsJournal of Biological Chemistry, 1965
- PATHWAYS OF ENZYMIC SYNTHESIS AND CONVERSION TO CHOLESTEROL OF DELTA5,7,24-CHOLESTATRIEN-3BETAO1 AND OTHER NATURALLY OCCURRING STEROLS1965
- 1117. A convenient synthesis of [9,19-3H2]cholecalciferol 3,5-dinitrobenzoate and the mechanism of the precholecalciferol ? calciferol reactionJournal of the Chemical Society, 1965
- CONVERSION OF DELTA7-CHOLESTENOL-4-C14 AND 7-DEHYDROCHOLESTEROL-4-C14 TO CHOLESTEROL1961