In male mice of strain A, orchiectomy decreased the incidence of degenerative joint disease. Homeotransplants of adrenals or ovaries further inhibited the development of the articular lesions. Anterior hypophyseal transplants increased the incidence and accelerated the onset of the joint disease. The effects of grafted hypophyses on the joints were counteracted by transplanted adrenals or ovaries, the ovaries being more effective in this respect than the adrenals.