Lymphotoxin: An anticarcinogenic lymphokine as measured by inhibition of chemical carcinogen or ultraviolet-irradiation-induced transformation of syrian hamster cells
- 15 January 1981
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 27 (1), 45-49
- https://doi.org/10.1002/ijc.2910270108
Abstract
Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinogen treatment varies directly with lymphotoxin concentration. The frequency of transformation does not change following re-feeding with lymphotoxin-free medium and incubation for 6 additional days. Furthermore, transformation by ultraviolet is prevented when cells are pulsed with lymphotoxin for as few as 6 hours after irradiation. Thus, lymphotoxin has the potential to irreversibly inhibit the first recognizable morphologic step of carcinogenesis.This publication has 16 references indexed in Scilit:
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