Passage of macromolecules between alveolar and interstitial spaces in foetal and newly ventilated lungs of the lamb

Abstract

1. Experiments were performed on exteriorized foetal lambs to measure transfer of macromolecules (proteins and [¹²⁵I]PVP) between lung alveolar liquid (A_l) and lung interstitial liquid as represented by lung lymph (L_ly). Transfer was measured in the foetus and during a 2 hr period of positive pressure ventilation.