Increased AF1q gene expression in high‐risk myelodysplastic syndrome
Open Access
- 13 December 2004
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 128 (2), 218-220
- https://doi.org/10.1111/j.1365-2141.2004.05306.x
Abstract
The AF1q gene is expressed in normal haematopoietic progenitors, but less so in differentiated blood cells. In 47 patients with myelodysplastic syndrome (MDS), AF1q copy numbers were 0–6·8 × 106/μg RNA compared with 1·5–2·4 × 105/μg RNA in normal marrow. AF1q levels correlated with international prognostic scoring system (IPSS) scores (P = 0·004) and the risk of post‐transplant relapse (P = 0·05). Among IPSS high‐risk patients, survival correlated inversely with AF1q levels (P = 0·04). Thus, AF1q levels correlate with high‐risk MDS and may provide a marker for risk stratification.Keywords
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