A COMPARISON OF EXOPHTHALMOS AND TISSUE CHANGES INDUCED BY ACTIVE AND INACTIVATED THYROTROPHIC HORMONE*
- 1 July 1951
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 49 (1), 15-20
- https://doi.org/10.1210/endo-49-1-15
Abstract
A pituitary extract rich in thyrotropin loses its thyroid-stimulating quality after incubation with explants of thyroid tissue. It was demonstrated that the exophthalmos-producing factor of this inactivated pituitary extract is also lost. Similarly the capacity to produce histologic changes, consisting of alterations in the fat and the cellular reaction in the connective tissue throughout the body associated with exptl. exophthalmos are inactivated.Keywords
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