Endogenous hypergastrinemia and cell proliferation in the fundic mucosa in dogs

Abstract
Endogenous hypergastrinemia (PPr=0.84,P<0.01) was found between the serum gastrin levels and the DNA synthesis index values measured in the 4 animals before antral exclusion, after antral exclusion, and after antrectomy. These data support the hypothesis that the trophic effect of gastrin on the fundic mucosa can be elicited by physiological doses of endogenous hormone.