Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin
- 1 September 1985
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 61 (3-4), 265-270
- https://doi.org/10.1007/bf01251917
Abstract
Clorgyline, a selective MAO-A inhibitor, increased (5 times) rat pineal melatonin and N-acetyl-serotonin (NAS) content, and decreased 5-HIAA level by 80%. Deprenyl, a selective MAO-B inhibitor, did not change melatonin or other pineal indoles content. The data obtained show that inhibition of MAO-A but not B enzyme is responsible for pineal melatonin increase caused by MAO inhibitors. It is suggested that the stimulation of melatonin synthesis caused by MAO inhibitors may contribute to their antidepressive effect.Keywords
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