COMBINATION CHEMOTHERAPY OF 6-THIOGUANINE WITH VARIOUS ANTI-TUMOR AGENTS AGAINST MURINE LEUKEMIA L-1210
- 1 January 1977
- journal article
- research article
- Vol. 68 (5), 543-552
Abstract
Antitumor activity of 6-thioguanine against L-1210 leukemia in BDF1 mice was studied in combination with various antitumor agents with alkylating activity. Combination treatment with 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)1-nitrosourea hydrochloride (ACNU) showed excellent therapeutic effect against early and advanced L-1210 leukemia, the latter of which was refractory to each agent alone.This publication has 6 references indexed in Scilit:
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