Effect of Corticotropin and Growth Hormone on Allantoin Synthesis and Excretion in the Dog.

Abstract

The incorporation of ingested glycine-N15 and ammonium citrate-N15 into urinary allantoin of normal adult bitches was studied during control experiments and during treatment with growth hormone and corticotropin. Growth hormone increased the amount of ammonium citrate-N15 utilized for allantoin synthesis, while corticotropin did not. Neither hormone increased incorporation of N15 from glycine into allantoin. Corticotropin increased output of urinary allantoin without markedly reducing the specific enrichment with N15. One possible interpretation of this finding is increased allantoin synthesis, without qualitative changes in its origin.