Effects of Nicotinic Acid and Some of its Homologues on Lipolysis, Adenyl Cyclase, Phosphodiesterase and Cyclic AMP Accumulation in Isolated Fat Cells

Abstract

Isolated fat cells from male rats were used to study the effects of nicotinic acid and some of its homologues upon lipolysis, adenyl cyclase, phosphodiesterase and cyclic-3’, 5’-AMP production. Only nicotinic acid and 3-pyridylacetic acid inhibited lipolysis, adenyl cyclase and cyclic AMP production consistently although some activity was found with ω(3-pyridyl) acrylic acid. None of the compounds tested altered phosphodiesterase activity. The data suggest that the antilipolytic compounds mediate their effects via the inhibition of cyclic AMP synthesis.