Comparative gene mapping: murine lambda light chain genes are located in region cen→B5 of mouse chromosome 16 not homolous to human chromosome 21
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 33 (3), 267-271
- https://doi.org/10.1159/000131769
Abstract
We have mapped the genes for murine immunoglobulin lambda light chains to the region of chromosome 16 proximal to band B5 by hybridizing a cDNA probe for X light chains to the DNA of a series of hybrid clones made between mouse fibroblasts carrying Searle’s translocation, T(X;16)16H, and Chinese hamster cells. Based on homology, we predict that the human Igl genes (IGL) will map to the proximal two-thirds of HSA 22.Keywords
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