The localization of aggregated human -globulin in the spleens of normal mice.

Abstract

The localization of aggregated human γ-globulin in the germinal centres of the white pulp of the spleens of normal mice was found to be dependent on the ability of the spleen to concentrate this material from the blood and of lymphoid cells in the mantle layer of the Malpighian bodies to take it up on their surface membranes. The fact that lymphoid cells resident in the spleen perform this function was shown by the inability of lymphoid cells transferred to recipient animals to transport the aggregated material to the spleens of the latter.