The following case report confirms the prediction that tuberculous persons whose organisms have become resistant to streptomycin may transmit such resistant tubercle bacilli to those with whom they come in contact. REPORT OF CASE J. Q. C., a Negro hospital attendant aged 32, was admitted to the Veterans Administration Hospital, Washington, D. C., on May 13, 1947 for chills, fever, generalized weakness, muscular pains, nausea and vomiting. Physical examination revealed a few scattered fine rales in the lower axillary region on the right side and a moderately loud friction rub. During the first week of hospitalization the patient had several chills and continued to have an elevation of temperature as high as 104.4 F. On the seventh day of hospitalization physical and roentgen examination revealed the presence of. a pleural effusion. Thoracentesis yielded 460 cc. of clear fluid which was proved, by culture and guinea pig inoculation, to contain tubercle