Treatment of Brain Disease with Dietary Precursors of Neurotransmitters

Abstract

A growing number of brain diseases [human] are characterized by decreased levels of one or more of the neurotransmitters. Recent experimental evidence indicates that nutritional factors strongly influence the regulation of the neurotransmitters, serotonin and acetylcholine. Attempts are now being made to treat diseases associated with low levels of serotonin or acetylcholine by administering their dietary precursors, tryptophan and choline, respectively. This treatment may increase the amount of the deficient neurotransmitter at synapses and produce clinical benefit. Such efforts to elevate brain neurotransmitter levels with a naturally occurring precursor represent a new approach in medical therapeutics and will probably continue. The scientific basis for such treatment was reviewed and showed that brain levels of serotonin and acetylcholine depend on the amounts of tryptophan and choline available to the brain; these, in turn, fluctuate according to dietary factors.