Combined Rauwolfia-Hydralazine Therapy of Hypertensive Patients

Abstract

Controlled blood pressure responses of 13 hospitalized and 33 ambulatory patients with essential or apparent renal hypertension were studied following combined Rauwolfia-hydralazine therapy. Adequate persistent lowering occurred in most instances of mild or moderate, and frequently even severe, hypertension. Prior and concomitant administration of Rauwolfia largely prevented unpleasant effects of hydralazine, permitted smaller dosage and ease of administration and follow-up—often impossible with large dosage of hydralazine used alone.