Calicheamicin γ 1 I and DNA: Molecular Recognition Process Responsible for Site-Specificity
- 12 May 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4905), 697-699
- https://doi.org/10.1126/science.2717946
Abstract
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.This publication has 24 references indexed in Scilit:
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