On the pH-Dependence of the Reaction of Hemoglobin with Carbon Monoxide
- 1 April 1975
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 52 (3), 589-593
- https://doi.org/10.1111/j.1432-1033.1975.tb04030.x
Abstract
Flash-photolysis experiments were performed on solutions of carbonmonoxy hemoglobin (human Hb A) as function as pH. The fraction of fast reaction and the amount of photodissociation as produced by a given amount of light quanta has been analyzed in terms of the allosteric model of ligand binding by Monod, Wyman and Changeux. It is shown how the switch-over point of the allosteric transition from the T or R state is controlled by the protons, which act as allosteric effectors.Keywords
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