Studies on Bacterial Resistance to Streptomycin.

Abstract

1. Resistance to streptomycin can be induced by repeated transfer of various organisms in streptomycin containing media. 2. In the early logarithmic stage of growth, highly resistant mutants can be isolated, by chance selection, in a single transfer. 3. In most instances, acquired resistance to streptomycin is maintained. 4. Organisms resistant to streptomycin may retain their original virulence as measured by the bactericidal test. 5. The acquisition of resistance to streptomycin with the maintenance of virulence may have certain therapeutic implications.