Inhibition of Angiotensin-Converting Enzyme by SQ 14,225 in Anesthetized Dogs: Hernodynamic and Renal Vascular Effects

Abstract

The hemodynamic and renal vascular effects of SQ 14,225 [D-3-mercapto-2-methylpropanoyl-L-proline], a new angiotensin-converting enzyme inhibitor, were studied in mongrel dogs under pentobarbital anesthesia. A dose-related inhibition of the pressor and renal vasoconstrictor effects of AI [angiotensin I], but not of AII, were seen after SQ 14,225. After administration of SQ 14,225 (310 .mu.g/kg i.v.) a moderate decrease in arterial pressure and increase in renal flood flow were observed. The hypotension and renal vasodilation seen after SQ 14,225 could be due to loss of endogenous AII; however, an enhancement of endogenously produced bradykinin cannot be excluded.