Sulfation Preceding Deiodination of Iodothyronines in Rat Hepatocytes
- 1 July 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4605), 81-83
- https://doi.org/10.1126/science.6857270
Abstract
In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.This publication has 15 references indexed in Scilit:
- RAPID DEIODINATION OF TRIIODOTHYRONINE SULFATE BY RAT LIVER MICROSOMAL FRACTIONEndocrinology, 1983
- Characteristics of Iodothyronine Tyrosyl Ring Deiodination by Rat Cerebral Cortical Microsomes*Endocrinology, 1983
- Glutathione Deficiency Induced by Cystine and/or Methionine Deprivation Does Not Affect Thyroid Hormone Deiodination in Cultured Rat Hepatocytes and Monkey Hepatocarcinoma CellsEndocrinology, 1981
- Thyroid hormone metabolism in primary cultured rat hepatocytes. Effects of glucose, glucagon, and insulin.JCI Insight, 1981
- Sulfate Transfer to Thyroid Hormones and Their Analogs by Hepatic Aryl SulfotransferasesEndocrinology, 1981
- Iodothyronine 5′-Deiodinase from Rat Kidney: Substrate Specificity and the 5′-Deiodination of Reverse Triiodothyr onine *Endocrinology, 1980
- Kinetics of enzymic reductive deiodination of iodothyronines. Effect of pHBiochemical Journal, 1979
- Phenolic and nonphenolic ring deiodinations of iodothyronines in cultured hepatocarcinoma cell hemogenate from monkeyBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Active transport of triiodothyronine (T3) into isolated rat liver cellsFEBS Letters, 1978
- Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and in vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphationBiochemical Journal, 1977