A dose-response comparison between methadone and morphine self-administration
- 27 May 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 47 (2), 209-211
- https://doi.org/10.1007/bf00735825
Abstract
Rats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3 mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine sulfate. The results showed that number of infusions taken was an inverse function of unit dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The data also indicated that more morphine than methadone was self-administered.This publication has 5 references indexed in Scilit:
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