A comparison of patient survival and tumour growth kinetics in human bronchogenic carcinoma

Abstract

A series of 46 primary bronchogenic carcinomas for which thymidine labelling index (% TLI) (in all cases) and tumour doubling time (DTact) (in 13 cases) had previously been measured were followed up for 5 years and these data compared with length of postoperative survival, tumour volume at operation and pathological staging. We found no correlation between reduced survival and higher tumour % TLI, indeed the reverse may be true. Larger tumours tended to have higher labelling indices considering either primary tumour volume or ''T''-category. Five year survivors had smaller tumours, tended to have T1 tumours and Stage I disease but did not have significantly lower tumour % TLIs. No relationship was found between DTact and any other parameter.