Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy
- 14 March 2010
- journal article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 6 (4), 273-275
- https://doi.org/10.1038/nchembio.317
Abstract
A plant mutant that fails to accumulate morphine provides a genetic clue to identifying the last two enzymes in this alkaloid biosynthetic pathway. Surprisingly, the proteins are non-heme dioxygenases, thus expanding the range of this versatile class of catalysts.Keywords
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