Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia
- 5 July 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 253 (5015), 79-82
- https://doi.org/10.1126/science.1676542
Abstract
Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.Keywords
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