Automatic classification of two‐dimensional gel electrophoresis pictures by heuristic clustering analysis: A step toward machine learning
- 31 December 1987
- journal article
- research article
- Published by Wiley in Electrophoresis
- Vol. 9 (3), 136-142
- https://doi.org/10.1002/elps.1150090307
Abstract
The interpretation of two-dimensional gel electrophoresis (2-DGE) profiles can be facilitated by artificial intelligence and machine learning programs. We have incorporated into our 2-DGE computer analysis system (termed MELANIE-Medical Electrophoresis Analysis Interactive Expert system) a program which automatically classifies 2-DGE patterns using heuristic clustering analysis. This program is a step toward machine learning. In this publication, we describe the classification method and the preliminary results obtained with liver biopsy electrophoretograms. Heuristic clustering is also compared to other classification techniques.This publication has 11 references indexed in Scilit:
- HERMeS: A second generation approach to the automatic analysis of two‐dimensional electrophoresis gels. Part V: Data analysisElectrophoresis, 1987
- Immobilized pH gradients in capillary tubes and two‐dimensional gel electrophoresisElectrophoresis, 1986
- Computer analysis of two‐dimensional gels: Automatic matchingElectrophoresis, 1984
- The QUEST System for Computer-Analyzed Two-Dimensional Electrophoresis of ProteinsPublished by Elsevier ,1984
- Machine LearningPublished by Springer Nature ,1983
- An approach to completely automatic comparison of two-dimensional electrophoresis gels.Clinical Chemistry, 1982
- Some extensions to the GELLAB two-dimensional electrophoretic gel analysis system.Clinical Chemistry, 1982
- Design and implementation of a prototype Human Protein Index.Clinical Chemistry, 1982