A Monoclonal Antibody Specific for the Carboxy-Terminus of Angiotensin II
- 1 January 1984
- journal article
- research article
- Published by Mary Ann Liebert Inc in Hybridoma
- Vol. 3 (4), 373-376
- https://doi.org/10.1089/hyb.1984.3.373
Abstract
A monoclonal antibody specific for the carboxy-terminus of angiotensin II was produced from the somatic cell fusion between SP2/0 myeloma cells and spleen cells from CAF/J mice immunized with angiotensin II selectively coupled to thyroglobulin. The subcloned line D5-7R2 was augmented in the ascites form and shown to be specific for angiotensin II (octapeptide) and shorter angiotensin peptides. This antibody did not cross-react with angiotensin I (decapeptide). This selectivity will be important in clinical assays that measure angiotensin II in the presence of angiotensin I.This publication has 9 references indexed in Scilit:
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